The story revolves around Zyra Paez (Kim Chiu), whose relationship with Carl Mauricio (J. C. de Vera) has failed. She decides to give their relationship one more try, but soon finds herself filled with doubt over her life choices. The situation gets even more complex when she meets and befriends Ian Arcano (Dennis Trillo), a heart doctor who later become her confidante, leaving her trying to decide whether he may be “the one”.
